Tesamorelin is a synthetic polypeptide comprising 44 amino acids. It acts as an analog for human growth hormone-releasing hormone (GHRH). It exhibits stability and effectiveness superior to natural GHRH.

The addition of a trans-3-hexenoic acid group extends its half-life, while the modified N-terminal portion enhances pharmacokinetics and stability. The molecule’s modified N terminal portion also improves its pharmacokinetics and stability.

Tesamorelin binds to GHRH receptors in the pituitary gland, stimulating growth hormone (GH) secretion. It travels to the area beneath the hypothalamus at the base of the brain. The peptide’s action then promotes synthesis across the body. It secretes growth hormone (GH) into the bloodstream.

Synthetic GH, or somatropin, plays a role in shaping body composition. It may contribute to improved muscle growth, cell repair, and metabolism.

It impacts various codocytes, or target cells, to reduce fat mass. It impacts various codocytes, or target cells, to reduce fat mass. Some of these include myocytes, adipocytes, osteoblasts, and hepatocytes.

The stimulation of GH also releases insulin-like growth factor-1 (IGF-1). This hormone helps to break fat cells down and lower glucose levels. Some doctors use it for these applications, aiding in weight loss.

The peptide’s influence on GH and IGF-1 has implications for metabolic processes and muscle recovery. They promote vital functions in the liver, like lipolysis, growth, and glucose uptake. They also slow the process of cell death, prolonging essential physiological actions.

Research is exploring tesamorelin’s impact on lipid metabolism and fat distribution. Tesamorelin targets abdominal lipids. It may aid your body in breaking them down and metabolizing them. These actions could reduce fat around the belly.

Enhancing lipid metabolism could reduce subcutaneous fat in your body. Tesamorelin may also remove visceral fat. The increase in GH levels could break fatty stores down. It may also promote equalized fat and energy distribution.

Below are 17 other potential benefits of tesamorelin.

• Enhances cognition
• Reduces accumulating fat around the liver
• Aids in muscle growth and exercise recovery
• Promotes better energy use
• Reduces abdominal fat
• Increases strength and muscle mass
• Improves metabolism
• Increases IGF-1 production
• Improves stamina and vitality
• Boosts immune system functioning
• Promotes faster wound healing
• Reduces liver fat
• Combats joint and muscle pain
• Enhances skin elasticity
• Improves nail and hair health
• Reduces cholesterol levels
• Boosts cardiovascular health

Studies have shown improved cognition after tesamorelin use. It may enhance executive function and treat cognitive impairments. Some patients could also experience better short-term verbal memory.

Tesamorelin has gained recognition in athletic and bodybuilding communities. The release of GH could optimize your muscle mass and improve workout performance. It may also promote a leaner body composition and enhance joint strength.

Our bodies lose muscle mass as we age, leading to reduced mobility and weakness. An imbalanced hormone profile could cause muscle deficiencies. GH may also lower the breakdown and improve the synthesis of protein.

Pairing resistance training and weightlifting with tesamorelin therapy could enhance results. A consistent routine and diet may increase strength, endurance, and recovery.

GH may also promote slow-wave sleep and improve rest quality. The hormone works overnight on physiological processes. It may help improve muscle development, fat loss, memory, and immune function. Users could experience increased wakefulness and energy during the day.

Applications

Tesamorelin, FDA-approved in 2010 for HIV-related lipodystrophy, is now under investigation for broader research applications. HIV treatment uses antiretroviral drugs. These medications cause changes in the body’s fat distribution. HIV may lead to lipoatrophy (loss of fat tissue) around the face, arms, buttocks, and legs.

The virus also affects different fat types. It could cause lipohypertrophy (abnormal increase in fat distribution) around the neck, back, chest, and abdominal wall. This visceral adipose tissue (VAT) buildup is harmful. It could lead to cardiovascular and metabolic diseases.

Research indicates tesamorelin’s effectiveness in reducing visceral adipose tissue (VAT) and improving body composition. It could refine body composition and burn excess fat. It may enhance metabolism by regulating adiponectin. This hormone metabolizes fat and sugar and improves blood clot markers.

Patients with lipodystrophy often develop insulin resistance and high cholesterol. They may experience high lactic acid levels and coronary artery disease.

Tesamorelin may reduce liver fat content and improve muscle quality. It does so by increasing skeletal muscle density and decreasing muscle fat.

Theratechnologies Inc., a Canadian pharmaceutical company, approved tesamorelin for managing lipodystrophy. Doctors typically prescribe the brand name version, Egrifta. It isn't generic, so it’s equally effective. Different regions may have one or the other name.

Ongoing research explores its potential in managing non-alcoholic fatty liver disease (NAFLD) and nerve injury. Tesamorelin may also benefit patients with HIV who have undergone long-term antiretroviral therapy. It could have a positive effect on obesity and infrared radiation treatment.

A 2019 study demonstrated tesamorelin’s ability to increase muscle density and area in individuals with HIV and abdominal obesity. It involved 193 responders and 148 placebo participants. They all had similar demographics (83% Caucasian, 87% male).

Tesamorelin increased the density of four truncal muscle groups. It also enhanced the rectus and lean anterolateral/abdominal muscles. Researchers saw growth in the total surface area of the psoas and rectus muscles.

Many consider peptides a better alternative to HGH injections. The FDA doesn’t approve the latter and many experience harmful side effects from them. Tesamorelin could be a safer option, as it produces little to no adverse reactions. It may also be more effective than HGH injections.

Administration involves subcutaneous injection. It goes directly beneath the skin after dissolving the peptide in water. The abdominal area is the most common route. Follow your doctor’s advice and use the correct techniques when administering tesamorelin.

Safety and side effects

Peptides are a new area of research. Their safety and efficacy are evolving constantly. Consult with researchers or healthcare professionals specializing in peptide studies. They’ll help you make informed decisions that suit your profile and goals.

esamorelin’s safety profile is evolving with ongoing research; potential side effects should be monitored. In research settings, short-term use of tesamorelin is generally considered safe.

Extended research use requires careful monitoring of natural hormone levels and potential side effects. It may also increase the risk of developing type 2 diabetes. The peptide impacts insulin and IGF-1, which might cause unwanted side effects. Ensure you consult your doctor regularly to track progress.

Below are eight minor side effects of tesamorelin which may occur semi-frequently. Notify your doctor immediately if you experience them more often or more severely.

• Depression
• Nausea or vomiting
• Allergic reactions
• Skin rashes
• Hives
• Itching
• Pain, numbness, swelling, or itching at and around the injection site

Some minor side effects may decrease over time while on the treatment. Your body gradually gets used to the medicine in the first few weeks.

Below are 13 severe potential side effects. They’re uncommon, generally only occurring if there are underlying issues or counteractions. Consult your doctor if they persist for more than a day.

• Numbness or burning sensations in the feet and hands
• Muscle pain
• Extensive edema (swelling) of the lower or upper limbs, like ankles, hands, or feet
• Night sweats
• Excess rash
• Shortness of breath
• Irregular or fast heartbeat
• Lightheadedness or fainting
• Chest pain or tightness
• Excessive thirst and hunger
• Excess urination
• Palpitations
• Tiredness and weakness

Disclose medications and existing conditions to your doctor before starting tesamorelin therapy. Below are eight examples of what you should inform your doctor about.

• Recent head injury or surgery
• Diabetes
• Cancer
• Problems related to the pituitary gland
• Hormonal imbalances
• You take prednisone, simvastatin, cortisone, or ritonavir
• You drink alcohol or smoke cigarettes
• You use dietary supplements or other medications

Proper needle usage and disposal are crucial. Inspect the tesamorelin solution before using it. It should be clear and particle-free. Discard it if you notice any abnormalities like clouding or color changes.

Storing your vials correctly is also vital. Keep them in an enclosed container that won’t receive airflow or light. Place it in a refrigerator that doesn’t require constant opening and closing. Ensure pets and children stay away from the solutions.

Handle the vials with care and don’t shake the solution. Follow your doctor’s dosage guidelines and avoid making changes without consulting them. Take your dose before bedtime to maximize tesamorelin’s effectiveness while you sleep.

Frequently asked questions about tesamorelin

What is the origin of tesamorelin?

Tesamorelin originates from Canada, where Theratechnologies Inc. developed it to manage lipodystrophy. They created it to lower fat accumulation that occurred from HIV antiretroviral medication. It has since shown benefits in several other areas, including bodybuilding.

How does tesamorelin work?

Tesamorelin binds to receptors in the brain’s pituitary gland. This action stimulates growth hormone secretion into the bloodstream. GH potentially enhances protein production and energy levels. It may also improve metabolism and fat utilization.

What happens when human growth hormone levels are low?

Low growth hormone levels may cause issues in the body. GH is crucial for various physiological functions like metabolism, healing, and growth. It also aids bone and muscle development. Depression, fatigue, fat increase, and libido loss may occur when it’s low.

How long does it take to see results from tesamorelin?

The time it takes to see results from tesamorelin depends on individual factors. Your physical health, condition, and history impact the speed of results. The timeframe also depends on the dosage, personal reactions, and length of treatment.

Some users start experiencing minor results from peptide therapy within a month. It could take 3–6 months to see the full benefits of tesamorelin.

Is the tesamorelin peptide legal?

Yes, the tesamorelin peptide is legal. The FDA only approves it for HIV-related lipodystrophy treatment. Professional athletes can’t use it, as it’s unethical in competing events. Growth hormone supplementation may have performance-enhancing benefits.

Sports associations ban tesamorelin under unfair advantage rules. It’s on the list of prohibited substances from the World Anti-Doping Agency (WADA). Athletes caught using it could face a lifetime ban from professional events.

What is tesamorelin, and what are its research applications?

Tesamorelin is a synthetic polypeptide consisting of 44 amino acids that functions as an analog for human growth hormone-releasing hormone (GHRH). In research, it is studied for its potential to stimulate growth hormone (GH) secretion, investigate metabolic effects, explore muscle and fat tissue studies, and assess its impact on conditions such as HIV-related lipodystrophy.

Researchers are also examining its possible applications in obesity and other metabolic disorders.

How does tesamorelin stimulate growth hormone release?

Tesamorelin binds to GHRH receptors in the pituitary gland, prompting the release of growth hormone (GH) into the bloodstream. This stimulation of GH secretion can enhance protein synthesis, improve metabolic regulation, and potentially contribute to muscle growth and fat reduction. Research aims to understand the mechanisms and efficacy of this process in various conditions.

What evidence supports tesamorelin’s effects on muscle growth and recovery in research settings?

Studies have shown that tesamorelin can increase muscle density and mass, particularly in individuals with conditions such as HIV and abdominal obesity. Research indicates that tesamorelin's influence on GH and IGF-1 levels may enhance muscle growth and recovery.

For instance, a 2019 study demonstrated significant improvements in muscle area and density among participants treated with tesamorelin. Ongoing research continues to explore its effectiveness in these areas.