Question 1

Where to Buy Epithalon Amidate for Research

Accepted Answer

Epithalon amidate is available from Spartan Peptides as a research-grade tetrapeptide with independent HPLC purity documentation and mass spectrometry sequence verification. The amidate form (C-terminal amide modification) is preferred in research protocols that require enhanced resistance to carboxypeptidase degradation compared to the standard free acid form. Available for in vitro laboratory research only.

Question 2

What Is Epithalon Amidate?

Accepted Answer

Epithalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG), developed originally by Vladimir Khavinson's group at the Saint Petersburg Institute of Bioregulation and Gerontology. It is a synthetic analog of epithalamin, a peptide fraction extracted from the pineal gland and studied in the Soviet-era aging research program at that institution. The amidate form adds a C-terminal amide group in place of the free carboxylic acid, a common modification in peptide research intended to increase proteolytic stability by eliminating recognition by exopeptidases that cleave from the C-terminus. Published studies use both forms; check the original literature your protocol is based on to determine which form matches.

Question 3

Published Research Context

Accepted Answer

Epithalon has been investigated in published preclinical research for effects on telomere-related endpoints. Khavinson's group published work suggesting the peptide can activate telomerase in certain cell models, which attracted research attention in geroscience circles. The group also published studies in rodent models examining survival and aging biomarkers. Most published epithalon research originates from that single institution, with limited independent replication, a factor worth weighing in protocol design.

Question 4

Quality Standards for Epithalon Amidate Sourcing

Accepted Answer

Because epithalon is a short tetrapeptide, synthesis is relatively straightforward. But the amidate modification requires an additional synthetic step, and its success should be confirmed by mass spectrometry. The amidated form has a different molecular weight than the free acid (loss of OH, gain of NH2), which should be reflected in the COA mass spec data. Confirm the COA shows the correct molecular weight for the amidate form specifically. Suppliers who provide a generic epithalon COA without differentiating between free acid and amidated forms are not giving you the documentation you need to confirm you have the right compound.

Question 5

Storage

Accepted Answer

Store lyophilized epithalon amidate at minus 20 degrees Celsius, sealed, away from moisture. Once reconstituted, refrigerate at 4 degrees and use within 28 days with bacteriostatic water as solvent.

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