VEGF
Vascular Endothelial Growth Factor, a signaling protein that promotes the formation of new blood vessels (angiogenesis) in preclinical research models.
Definition
Vascular Endothelial Growth Factor (VEGF) is a family of signaling glycoproteins that regulate angiogenesis (formation of new blood vessels from pre-existing vasculature) and vasculogenesis (formation of new blood vessels from progenitor cells). VEGF-A is the primary angiogenic isoform and binds VEGF receptors (VEGFR-1 and VEGFR-2) on endothelial cells to stimulate proliferation, migration, and tubulogenesis. VEGF production is upregulated by hypoxia, growth factors, and inflammatory cytokines, linking it to tissue repair processes. VEGF signaling through VEGFR-2 (KDR/Flk-1) is the primary mediator of angiogenic responses in most tissues.
Research Context
VEGF is a central mediator in several research peptide mechanisms of action, particularly for compounds studied in tissue repair and wound healing research. BPC-157 has been documented to upregulate VEGF expression at injury sites in preclinical models, contributing to angiogenesis and improved tissue vascularization. GHK-Cu has also been studied for its effects on VEGF expression in dermal research models. Understanding VEGF pathway modulation is critical for interpreting preclinical results from wound healing, angiogenesis, and tissue regeneration compound studies.
Relevant Compounds
This term applies to the following research compound hubs.
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