BPC-157 Study Index
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide representing a partial sequence of the human gastric BPC protein. Its primary documented mechanism in preclinical models involves the nitric oxide synthesis pathway, VEGF and EGF receptor upregulation, and modulation of growth factor availability at tissue repair sites. The compound has been studied across gastrointestinal, tendon, CNS, and vascular research contexts in rodent models, with a large body of work originating from the Sikiric group at the University of Zagreb.
Studies Listed
6
Curated Study References
Click column headers to sort. PubMed links open in a new tab where available.
| Authors ↕ | Year ↓ | Journal ↕ | Key Finding | PubMed |
|---|---|---|---|---|
| Sikiric et al. | 2018 | Current Neuropharmacology | Review of BPC-157 CNS research documenting documented neuroprotective, antidepressant-relevant, and neurotransmitter system modulatory effects across multiple rodent CNS injury and behavioral models. | 28503116 ↗ |
| Sikiric et al. | 2016 | Current Pharmaceutical Design | Comprehensive review documenting BPC-157 effects on the gut-brain axis including dopaminergic, serotonergic, and GABAergic system modulation in rodent preclinical models. | 26139110 ↗ |
| Chang et al. | 2011 | Journal of Applied Physiology | BPC-157 promoted tendon outgrowth, fibroblast cell migration, and survival in both in vitro tendon ring culture and in vivo Achilles tendon transection models, implicating growth factor and NO signaling in its tendon repair mechanism. | 21030672 ↗ |
| Sikiric et al. | 2010 | Journal of Physiology, Paris | BPC-157 administration was associated with functional recovery and reduced spinal cord injury lesion extent in rodent spinal cord transection models, providing evidence for CNS neuroprotective properties. | 20096772 ↗ |
| Vukovic et al. | 2009 | Regulatory Peptides | BPC-157 promoted angiogenesis comparable to established growth factors in tendon, ligament, and bone repair models, with documented VEGF upregulation as a proposed mechanism for vascular support at repair sites. | 18790313 ↗ |
| Sikiric et al. | 1993 | Journal of Physiology, Paris | BPC-157 demonstrated dose-dependent cytoprotective effects on gastric mucosa in rat models of nitric oxide synthesis inhibition, suggesting involvement of the NO pathway in its protective mechanism. | 8255482 ↗ |
Sikiric et al.
2018, Current Neuropharmacology
Review of BPC-157 CNS research documenting documented neuroprotective, antidepressant-relevant, and neurotransmitter system modulatory effects across multiple rodent CNS injury and behavioral models.
Sikiric et al.
2016, Current Pharmaceutical Design
Comprehensive review documenting BPC-157 effects on the gut-brain axis including dopaminergic, serotonergic, and GABAergic system modulation in rodent preclinical models.
Chang et al.
2011, Journal of Applied Physiology
BPC-157 promoted tendon outgrowth, fibroblast cell migration, and survival in both in vitro tendon ring culture and in vivo Achilles tendon transection models, implicating growth factor and NO signaling in its tendon repair mechanism.
Sikiric et al.
2010, Journal of Physiology, Paris
BPC-157 administration was associated with functional recovery and reduced spinal cord injury lesion extent in rodent spinal cord transection models, providing evidence for CNS neuroprotective properties.
Vukovic et al.
2009, Regulatory Peptides
BPC-157 promoted angiogenesis comparable to established growth factors in tendon, ligament, and bone repair models, with documented VEGF upregulation as a proposed mechanism for vascular support at repair sites.
Sikiric et al.
1993, Journal of Physiology, Paris
BPC-157 demonstrated dose-dependent cytoprotective effects on gastric mucosa in rat models of nitric oxide synthesis inhibition, suggesting involvement of the NO pathway in its protective mechanism.
All citations are for informational research reference purposes. Always verify directly via PubMed for current status.
Research Questions
Common questions about BPC-157 research context, mechanism, and procurement.
What is BPC-157 and where does it originate?+
What does BPC-157 research show about tendon repair?+
Has BPC-157 been studied in CNS research models?+
Is BPC-157 approved for human therapeutic use?+
Related Compound Comparisons
Explore how BPC-157 compares to other research compounds.
Source BPC-157
BPC-157 is available from Spartan Peptides at least 98% HPLC-verified purity. Domestic US supply with same-day dispatch before 2 PM. For in-vitro research use only.
Order BPC-157 ($119)For in-vitro research use only. Not intended for human consumption.