Epithalon Study Index
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed by Dr. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a functional analog of Epithalamin, a polypeptide fraction isolated from bovine pineal gland. Its primary documented mechanism is activation of telomerase, specifically the catalytic subunit hTERT, in somatic cells that normally express this enzyme at low levels. Cell culture studies have reported telomere elongation and extension of cellular replicative capacity in Epithalon-treated models, and animal studies have examined its effects on melatonin secretion, immune function, and aging markers across multiple tissue types.
Studies Listed
6
Curated Study References
Click column headers to sort. PubMed links open in a new tab where available.
| Authors ↕ | Year ↓ | Journal ↕ | Key Finding | PubMed |
|---|---|---|---|---|
| Vinogradova et al. | 2021 | Advances in Gerontology | Epithalon treatment modulated melatonin secretion by the pineal gland in aged rats, providing evidence for its effects on circadian neuroendocrine regulation as a component of its anti-aging mechanism. | N/A |
| Khavinson et al. | 2010 | Journal of Anti-Aging Medicine | Epithalon administration in aged primates restored neuroendocrine regulatory parameters toward values observed in younger animals, extending the evidence for anti-aging effects into primate models. | N/A |
| Anisimov et al. | 2006 | Bulletin of Experimental Biology and Medicine | Epithalon reduced spontaneous tumor incidence, extended mean lifespan, and improved aging biomarker profiles in Swiss-derived SHR mice, adding to the body of evidence for organismal anti-aging effects in mammalian models. | 17369895 ↗ |
| Khavinson et al. | 2003 | Bulletin of Experimental Biology and Medicine | Epithalon induced telomerase activity and produced measurable telomere elongation in cultured human somatic cells, providing the primary mechanistic evidence for its role in cellular longevity research. | 14564039 ↗ |
| Anisimov et al. | 2003 | Mechanisms of Ageing and Development | Long-term Epithalon treatment in transgenic mice significantly reduced tumor incidence and extended maximal lifespan compared to controls, providing organismal-level evidence for anti-aging properties in an accelerated aging model. | 12631439 ↗ |
| Khavinson et al. | 2002 | Neuro Endocrinology Letters | Epithalon administration extended mean and maximum lifespan in Drosophila melanogaster models, providing invertebrate evidence for lifespan extension properties consistent with its telomerase-activating mechanism. | 12181565 ↗ |
Vinogradova et al.
2021, Advances in Gerontology
Epithalon treatment modulated melatonin secretion by the pineal gland in aged rats, providing evidence for its effects on circadian neuroendocrine regulation as a component of its anti-aging mechanism.
Khavinson et al.
2010, Journal of Anti-Aging Medicine
Epithalon administration in aged primates restored neuroendocrine regulatory parameters toward values observed in younger animals, extending the evidence for anti-aging effects into primate models.
Anisimov et al.
2006, Bulletin of Experimental Biology and Medicine
Epithalon reduced spontaneous tumor incidence, extended mean lifespan, and improved aging biomarker profiles in Swiss-derived SHR mice, adding to the body of evidence for organismal anti-aging effects in mammalian models.
Khavinson et al.
2003, Bulletin of Experimental Biology and Medicine
Epithalon induced telomerase activity and produced measurable telomere elongation in cultured human somatic cells, providing the primary mechanistic evidence for its role in cellular longevity research.
Anisimov et al.
2003, Mechanisms of Ageing and Development
Long-term Epithalon treatment in transgenic mice significantly reduced tumor incidence and extended maximal lifespan compared to controls, providing organismal-level evidence for anti-aging properties in an accelerated aging model.
Khavinson et al.
2002, Neuro Endocrinology Letters
Epithalon administration extended mean and maximum lifespan in Drosophila melanogaster models, providing invertebrate evidence for lifespan extension properties consistent with its telomerase-activating mechanism.
All citations are for informational research reference purposes. Always verify directly via PubMed for current status.
Research Questions
Common questions about Epithalon research context, mechanism, and procurement.
What is Epithalon and who developed it?+
What telomerase research has been conducted on Epithalon?+
What lifespan research exists for Epithalon in animal models?+
What is the relationship between Epithalon and melatonin in research models?+
Related Compound Comparisons
Explore how Epithalon compares to other research compounds.
Source Epithalon
Epithalon is available from Spartan Peptides at least 98% HPLC-verified purity. Domestic US supply with same-day dispatch before 2 PM. For in-vitro research use only.
Order Epithalon ($199)For in-vitro research use only. Not intended for human consumption.