Kisspeptin Study Index
Kisspeptin is an endogenous neuropeptide that serves as the primary upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It activates the G-protein coupled receptor GPR54 (KISS1R) on GnRH neurons in the hypothalamic arcuate and anteroventral periventricular nuclei, driving the pulsatile release of GnRH that controls downstream LH, FSH, and gonadal steroid secretion. Kisspeptin was identified as a tumor metastasis suppressor before its reproductive role was recognized, and the 2003 NEJM paper by Seminara et al. linking GPR54 loss-of-function mutations to idiopathic hypogonadotropic hypogonadism established it as the gatekeeper of puberty and fertility.
Studies Listed
6
Curated Study References
Click column headers to sort. PubMed links open in a new tab where available.
| Authors ↕ | Year ↓ | Journal ↕ | Key Finding | PubMed |
|---|---|---|---|---|
| Young et al. | 2019 | Nature Reviews Endocrinology | Comprehensive review documenting the role of Kisspeptin as the central integrator of endocrine, metabolic, and environmental signals regulating the HPG axis, including its role in puberty, fertility, and the neuroendocrine basis of reproductive disorders. | 31636404 ↗ |
| Jayasena et al. | 2014 | Journal of Clinical Investigation | Repeated Kisspeptin-54 administration over 8 weeks in women with hypothalamic amenorrhea restored pulsatile LH secretion and menstrual cyclicity in a majority of subjects, demonstrating its potential as a reproductive axis restoration tool in human clinical studies. | 24713654 ↗ |
| Jayasena et al. | 2011 | Human Reproduction | Kisspeptin-54 administration successfully triggered oocyte maturation in women undergoing IVF, providing direct evidence for its clinical application in reproductive medicine as an alternative gonadotropin trigger without OHSS risk. | 21747115 ↗ |
| Dhillo et al. | 2007 | Journal of Clinical Endocrinology and Metabolism | Kisspeptin-54 stimulated LH and FSH release in women with the most potent response observed during the preovulatory phase, demonstrating that the magnitude of Kisspeptin-driven gonadotropin release is regulated by the hormonal context of the menstrual cycle. | 17895322 ↗ |
| Dhillo et al. | 2005 | Journal of Clinical Endocrinology and Metabolism | Kisspeptin-54 administration in healthy men produced robust dose-dependent LH secretion, providing the first direct human evidence that Kisspeptin acutely stimulates the HPG axis in a clinically relevant manner. | 16174730 ↗ |
| Seminara et al. | 2003 | New England Journal of Medicine | Loss-of-function mutations in GPR54 (the Kisspeptin receptor) caused idiopathic hypogonadotropic hypogonadism in humans and mice, establishing Kisspeptin as the essential upstream regulator of the GnRH axis and thus of puberty and reproduction. | 14695410 ↗ |
Young et al.
2019, Nature Reviews Endocrinology
Comprehensive review documenting the role of Kisspeptin as the central integrator of endocrine, metabolic, and environmental signals regulating the HPG axis, including its role in puberty, fertility, and the neuroendocrine basis of reproductive disorders.
Jayasena et al.
2014, Journal of Clinical Investigation
Repeated Kisspeptin-54 administration over 8 weeks in women with hypothalamic amenorrhea restored pulsatile LH secretion and menstrual cyclicity in a majority of subjects, demonstrating its potential as a reproductive axis restoration tool in human clinical studies.
Jayasena et al.
2011, Human Reproduction
Kisspeptin-54 administration successfully triggered oocyte maturation in women undergoing IVF, providing direct evidence for its clinical application in reproductive medicine as an alternative gonadotropin trigger without OHSS risk.
Dhillo et al.
2007, Journal of Clinical Endocrinology and Metabolism
Kisspeptin-54 stimulated LH and FSH release in women with the most potent response observed during the preovulatory phase, demonstrating that the magnitude of Kisspeptin-driven gonadotropin release is regulated by the hormonal context of the menstrual cycle.
Dhillo et al.
2005, Journal of Clinical Endocrinology and Metabolism
Kisspeptin-54 administration in healthy men produced robust dose-dependent LH secretion, providing the first direct human evidence that Kisspeptin acutely stimulates the HPG axis in a clinically relevant manner.
Seminara et al.
2003, New England Journal of Medicine
Loss-of-function mutations in GPR54 (the Kisspeptin receptor) caused idiopathic hypogonadotropic hypogonadism in humans and mice, establishing Kisspeptin as the essential upstream regulator of the GnRH axis and thus of puberty and reproduction.
All citations are for informational research reference purposes. Always verify directly via PubMed for current status.
Research Questions
Common questions about Kisspeptin research context, mechanism, and procurement.
What is Kisspeptin and what is its role in the reproductive axis?+
What human LH stimulation research exists for Kisspeptin?+
Has Kisspeptin been studied in hypothalamic amenorrhea research?+
What IVF-related research has been conducted on Kisspeptin?+
Related Compound Comparisons
Explore how Kisspeptin compares to other research compounds.
Source Kisspeptin
Kisspeptin is available from Spartan Peptides at least 98% HPLC-verified purity. Domestic US supply with same-day dispatch before 2 PM. For in-vitro research use only.
Order Kisspeptin ($149)For in-vitro research use only. Not intended for human consumption.