TB-500 Study Index
TB-500 is a synthetic analog of the actin-binding ADS motif of Thymosin Beta-4 (Tβ4), an endogenous actin-sequestering protein expressed in virtually all nucleated mammalian cells. Its primary mechanism involves sequestration of G-actin (monomeric actin), which regulates the availability of actin monomers for filament polymerization and thereby controls cellular migration, wound closure, and cytoskeletal organization. Research has also documented anti-inflammatory, angiogenic, and cardiac protective properties in preclinical models of tissue injury.
Studies Listed
6
Curated Study References
Click column headers to sort. PubMed links open in a new tab where available.
| Authors ↕ | Year ↓ | Journal ↕ | Key Finding | PubMed |
|---|---|---|---|---|
| Goldstein et al. | 2012 | Annals of the New York Academy of Sciences | Comprehensive review of Thymosin Beta-4 biology documenting anti-inflammatory, angiogenic, cell survival, and tissue repair mechanisms with proposed clinical applications across cardiac, wound healing, and neurological models. | 22994907 ↗ |
| Sosne et al. | 2010 | Investigative Ophthalmology and Visual Science | TB-500 parent compound Thymosin Beta-4 suppressed osteoclast formation in bone remodeling models, suggesting anti-inflammatory and bone homeostasis relevant mechanisms beyond soft tissue repair. | 19846855 ↗ |
| Smart et al. | 2007 | Nature Medicine | Thymosin Beta-4 (the parent compound of TB-500) induced mobilization of epicardial progenitor cells and neovascularization in adult mouse cardiac tissue following myocardial infarction, providing mechanistic support for cardiac repair applications. | 17572687 ↗ |
| Bock-Marquette et al. | 2004 | Nature | Thymosin Beta-4 activated integrin-linked kinase (ILK) in cardiomyocytes, promoting cell survival and migration in a mouse model of myocardial infarction, identifying ILK as a key effector in the cardiac repair mechanism. | 15254532 ↗ |
| Sosne et al. | 2002 | Experimental Eye Research | Thymosin Beta-4 topical administration promoted corneal epithelial healing and reduced inflammatory cell infiltration following alkali-induced corneal injury in mouse models, documenting anti-inflammatory and repair properties. | 12161821 ↗ |
| Goldstein et al. | 1977 | Proceedings of the National Academy of Sciences | Landmark paper establishing the isolation and characterization of thymosin peptides from thymic tissue, providing the foundational research basis for the Thymosin Beta-4 ADS fragment that TB-500 is derived from. | 265583 ↗ |
Goldstein et al.
2012, Annals of the New York Academy of Sciences
Comprehensive review of Thymosin Beta-4 biology documenting anti-inflammatory, angiogenic, cell survival, and tissue repair mechanisms with proposed clinical applications across cardiac, wound healing, and neurological models.
Sosne et al.
2010, Investigative Ophthalmology and Visual Science
TB-500 parent compound Thymosin Beta-4 suppressed osteoclast formation in bone remodeling models, suggesting anti-inflammatory and bone homeostasis relevant mechanisms beyond soft tissue repair.
Smart et al.
2007, Nature Medicine
Thymosin Beta-4 (the parent compound of TB-500) induced mobilization of epicardial progenitor cells and neovascularization in adult mouse cardiac tissue following myocardial infarction, providing mechanistic support for cardiac repair applications.
Bock-Marquette et al.
2004, Nature
Thymosin Beta-4 activated integrin-linked kinase (ILK) in cardiomyocytes, promoting cell survival and migration in a mouse model of myocardial infarction, identifying ILK as a key effector in the cardiac repair mechanism.
Sosne et al.
2002, Experimental Eye Research
Thymosin Beta-4 topical administration promoted corneal epithelial healing and reduced inflammatory cell infiltration following alkali-induced corneal injury in mouse models, documenting anti-inflammatory and repair properties.
Goldstein et al.
1977, Proceedings of the National Academy of Sciences
Landmark paper establishing the isolation and characterization of thymosin peptides from thymic tissue, providing the foundational research basis for the Thymosin Beta-4 ADS fragment that TB-500 is derived from.
All citations are for informational research reference purposes. Always verify directly via PubMed for current status.
Research Questions
Common questions about TB-500 research context, mechanism, and procurement.
What is TB-500 and how does it relate to Thymosin Beta-4?+
What cardiac repair research exists for TB-500?+
How does TB-500 affect wound healing in preclinical models?+
Is TB-500 available for research procurement?+
Related Compound Comparisons
Explore how TB-500 compares to other research compounds.
Source TB-500
TB-500 is available from Spartan Peptides at least 98% HPLC-verified purity. Domestic US supply with same-day dispatch before 2 PM. For in-vitro research use only.
Order TB-500 ($169)For in-vitro research use only. Not intended for human consumption.