Certificate of Analysis
A quality document accompanying each research peptide lot that reports purity, identity, molecular weight, and other analytical test results.
Definition
A Certificate of Analysis (CoA) is a quality assurance document issued for each production lot of a research compound that reports the results of analytical testing performed on that specific batch. For research-grade peptides, a CoA typically includes: the compound name and molecular formula, the lot or batch number, the manufacturing or testing date, HPLC purity percentage with chromatogram data, mass spectrometry molecular weight confirmation, and sometimes additional tests such as residual solvent analysis, water content (Karl Fischer titration), and microbial testing. The CoA serves as the primary documentation of lot-specific quality for research procurement decisions.
Research Context
The certificate of analysis is the most important quality document a researcher should request and review when procuring research-grade peptide compounds. HPLC purity data and MS identity confirmation on the CoA provide direct evidence that the compound meets its purity specification and has the correct molecular identity. Researchers conducting rigorous preclinical studies should archive CoAs for all lots used in published experiments, as this information is required for complete materials and methods reporting and for study reproducibility assessments.
Relevant Compounds
This term applies to the following research compound hubs.
Frequently Asked Questions
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